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Information about Pregabalin

Use this section to discuss any medications or even natural remedies that you have used or are using to cope or to control your BFS symptoms or Anxiety symptoms.

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Information about Pregabalin

Postby Monty1973 » Fri Jul 29, 2016 10:15 pm

Hi everyone

After my recent neuro appointment the neuro recommended by letter to my GP Pregabalin to deal with the neuropathic pain resulting from my BFS. However, my GP has refused to prescribe it to me due to what he says are its side effects. Could anyone please give me some information about this medication and how effective it is at tackling neuropathic pain and also if there are any other recommended medications for neuropathic pain. Unfortunately my neuro did not recommend any other alternatives to deal with my pain.
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Re: Information about Pregabalin

Postby banjanti » Sat Jul 30, 2016 3:11 am

Pregabain is safe but can make you feel weird and spaced out, if your gp didn't want to give you it I doubt he will go the route of tricyclic antidepressants or calcium channel blockers, when it comes to last one risk of SJS is too big even for me and I'm desperate
Another group is SNRI but it can and most likely make twitch more
The thing is "neuropathic pain" in BFS is not coming from damaged nerves, the only location that is responsible for both pain and hyperexcitability would be Kv7 channels, so logically VGKC openers would work best
But as I suggested before try medical marijuana if it's a possibility as it's safer than everything else mention
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Re: Information about Pregabalin

Postby yuliasir » Sat Jul 30, 2016 5:21 am

Pregabaline is small molecule similar to naturalbrain neuromediator GABA and generally is well tolerated and considered as safe. It is really good for neuropatic pain and does not create any psychological or physiological dependency as far as I remember (but I may be wrong of course).
The only known side effects (as far as I know) is a kind of drowziness for the firts week or two (remember that dose should be minimum 300 mg/day). I was taking it as a part of my own treatment and I am still OK :)))

And I agree with the banjanti, if your GP is not agree on Lyrica, hardly he or she could agree on more 'heavy artillery' like tryciclics etc. Maybe it is worth to talk to GP and ask him or her about explanation... or at least about alternatives he or she prefers? On my point of view, pregabalin might be one of the safest among other drugs to deal with neurogenic pains, since they are stubborn and could not be removed by convention analgetics like ibuprophen etc.


It may cause some dependency but only in low percent of population (figures are 1 to 4 %) in doses above 600 mg/day... but usually pain treatment course lasts not long enough to let it developed. Another bad effect for gents is erectile disfunction (being female, I had not that problem, and my libido was anyways suppressed by fears so for me it was rather vice versa effect).

Sorry that your choice is limited becasue of your GP decision.
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Re: Information about Pregabalin

Postby Monty1973 » Sat Jul 30, 2016 8:21 am

Thank you Yula and Banjanti for spending the time in getting back to my query. I am just really frustrated by my GP who did not suggest any alternatives even though I have been to see him numerous times about the pain I am experiencing. Although I got the all clear from the neuro the GP didn't even really look or go through his letter with me. To cap it all I now have some non BFS related concerns. I had two blood tests which showed slightly elevated tumour markers on Alpha Protein and neurone specific enolase (nothing to do at all with my BFS but it is related to small lung cell cancer). I am now so worried and can't stop crying. Because my blood test were carried out privately even though they were carried out at a well known private hospital my GP initially refuse to see me. He then came back to me and said he would see me but only for a routine appointment in 10 days times. This has not helped my anxiety at all. I am going to see a private GP on Monday morning about it then I will change my normal GP later in the week. It has been a really distressing few months what with the BFS and now these blood tests. I suppose I do have the reassurance that about four months ago that when I was admitted to accident and emergency with high blood pressure due to my anxiety the doctors conducted out a chest x ray and it was normal. I would have thought they might have picked up on something there if there was a concern. My other tumour marker tests and blood tests were also fine. Just really worried and hoping the private GP will be better on Monday.
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Re: Information about Pregabalin

Postby yuliasir » Sat Jul 30, 2016 8:48 am

Hi Monty

I am not a specialist in immunoassays and markers, so can not advice a lot about your test results... But if you are not referred officially to oncologist right now, I do not think you need to draw cancer diagnosis on yourself. I know that onco markers are not absolute and from what I had translated (and I did a lot of that stuff) various tissues can produce proteins associated with tumors, and normal tissues also can do that. You need a proper consultation I think in order to decide how to proceed, but unfortunately I could nto provide any deep insight on that.
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Re: Information about Pregabalin

Postby Monty1973 » Sat Jul 30, 2016 9:01 am

Hi Yula

Thank you for your quick reply. I suppose in some ways it is reassuring in a way that my GP does not want to see me straightaway but he has not been the most sympathetic GP over the last couple of months. Because of the anxiety about the blood tests I am going to see a private GP on Monday and get some advice about the blood test results. I will let you know how the consultation goes. Take care, Andrew
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Re: Information about Pregabalin

Postby Monty1973 » Sat Jul 30, 2016 9:17 am

Hi Yula

I suppose my worries have now moved on to paraneoplastic syndrome, but I was thinking this can't be a consideration as my emg and nerve conduction study did not find anything abnormal apart from some hyperexcitability of nerves, which the neuro thinks has been precipitated by my recent breakdown and the distress and anxiety this has caused.
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Re: Information about Pregabalin

Postby Sunny2141 » Sat Jul 30, 2016 3:23 pm

I have taken Lyrica (pregabalin) since this whole mess started and actually DID and still do have some good results with it. I am not taking the therapeutic dose which was recommended and maybe I should take it at that level!!! My first symptoms were buzzing internally before the twitches started and I have to say that within two weeks of taking 75 mg for Lyrica at bedtime, the buzzing completely stopped! It was a miracle to me as it was an incessant nonstop internal buzzing down in my lower spine near tailbone and was very strange and distracting.

The doctor wanted me to UP the Lyrica to 150 mg a day which is the minimum therapeutic dose and I went the opposite direction as I didn't want side effects. I asked for a lower dose (50 mg) just to take at bedtime which I took for the last two months. It did help me to sleep a little. When my hand pain worsened, I decided to up the dose at bedtime back to the 75 mg and it DID help my sleep improve. Banjanti is right that it can make you a little groggy or spacey, but I think some of that can be acclamated by slowing increasing the dose.

Given that my recent steroid injection in the spine only minimally helped (but it did help) my hand pain issues, I am thinking of increasing the Lyrica dosage to see if I can get my nerves to settle down further. I don't think I really gave Lyrica the proper chance to work by taking such a low dose.

I am having a wierd twictch/spasm that is completely non-stop on the outside of my palm under pinky (hypothenar eminence) and is causing writer's cramp and generalized pain and forearm pain. It has overshadowed the pain I was having in my palm, which I think was helped by the cervical injection. I have been wondering if increasing Lyrica might settle it down.

I will keep you posted on this. Just a note - they can prescribe Lyrica at 25 mg dosage, so you can supplement the normal 75 mg pills in small increments. Some pharmacies say the only dose is 75 mg a pill or higher ... That is not true. I am glad for Yuliasir's post to know she took it at higher levels with no issues.

Blessings and be well.
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Re: Information about Pregabalin

Postby Monty1973 » Mon Aug 01, 2016 4:47 pm

Thank you Banjanti, Yula and Linda for your advice and information about Pregabalin. I saw the private GP today, who could not understand why my normal GP had not at least given me the option of trying Pregablin. The private GP said that he could prescribe it to me after I receive the results of my blood tests and chest-x ray, which I had done today. It was nice to have someone to listen to me and I am changing my GP this week. Maybe the Pregablin will help to settle the pain down a bit, which means I can get back to doing some exercise. I was wondering if any of you have experienced pain in your shoulders as a result of BFS/BCS or what feels like a low rumbling sound in the ears. I have this incessant pain in my right shoulder at the moment. The private GP suggested also that some of the pain could be a somatisation of underlying stress. This does seem plausible as the problem reared its head in March when I was having a lot of stress with my job as a University lecturer. I think I still have the fear about cancer as the pain is still widespread and I experience a lot of fatigue. I suppose the blood tests that I have this week would reveal anything nasty going on. I will let you know how I get on with Pregabalin and if it helps with the pain. Take care, Andrew
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Re: Information about Pregabalin

Postby yuliasir » Fri Aug 05, 2016 5:37 pm

I do have rumbling noise in my ears especially when I move my eyes or just without any good reason. Suppose I had it for all my life. Annoying but harmless.
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